General principles of therapy
Goals
The goals of therapy for chronic hepatitis C include prevention of progressive liver disease, control of extrahepatic manifestations (where present) and decreasing the infectivity of patients with HCV infection. These end points are difficult to measure and may take many years to evaluate, given the prolonged natural history of this condition. Efforts at therapy have therefore focused on elimination of HCV infection which is almost always associated with improvement in the severity of liver disease as assessed by liver biopsy.